Advances in healthcare have led to an extended life expectancy throughout the developed world, but cognitive impairment in later life, and Alzheimers disease AD in particular, remains one of the intractable problems which can blight quality of life as we age. Depression in Alzheimers disease is an additional factor which has a significant impact on disability, disease progression, and caregiver burden.This book, volume 4 of the Advances in Alzheimers Disease book series which is published in coordination with the Journal of Alzheimers Disease, presents papers which reflect the progress in recent years of research