This book is about the Microhardness and Impact strength of heat cure acrylic resins after immersed into hospital based disinfectants and commerically available denture cleansers. Denture disinfection is an essential component which is related to the health of the patients but at the same time many disinfectants regimes adversely affect the properties of the acrylic resins. Through the outcomes of this study one can easily prescribed a suitable disinfectant which effectively remove the bioburden of microorganisms from the prosthesis without adversely affecting the properties.