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Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume 2: Safety Assessment and Toxicologic Pathology: Haschek and Rousseaux's Handbook of Toxicologic Pathology, cartea 2

Editat de Wanda M. Haschek, Colin G. Rousseaux, Matthew A. Wallig, Brad Bolon
en Limba Engleză Hardback – 5 iun 2023

Haschek and Rousseaux's Handbook of Toxicologic Pathology, recognized by many as the most authoritative single source of information in the field of toxicologic pathology, has been extensively updated to continue its comprehensive and timely coverage. The fourth edition has been expanded to four separate volumes due to an explosion of information in this field requiring new and updated chapters.

Completely revised with a number of new chapters, Volume 2 encompasses "Toxicologic Pathology in Safety Assessment" and "Environmental Toxicologic Pathology". These two sections cover the application of toxicologic pathology in developing specific product classes, principles of data interpretation for safety assessment, and toxicologic pathology of major classes of environmental toxicants. Other volumes in this work round out the depth and breadth of coverage. Volume 1, "Principles and the Practice of Toxicologic Pathology," covers the practice of toxicologic pathology in three parts: Principles of Toxicologic Pathology, Methods in Toxicologic Pathology, and the Practice of Toxicologic Pathology. Volumes 3 and 4 provide deep and broad treatment of "Target Organ Toxicity", emphasizing the comparative and correlative aspects of normal biology and toxicant-induced dysfunction, principal methods for toxicologic pathology evaluation, and major mechanisms of toxicity. These volumes comprise the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists, and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants. Each volume is being published separately.

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Specificații

ISBN-13: 9780128210475
ISBN-10: 0128210478
Pagini: 692
Ilustrații: Approx. 200 illustrations (200 in full color)
Dimensiuni: 216 x 276 x 40 mm
Greutate: 2.09 kg
Ediția:4
Editura: ELSEVIER SCIENCE
Seria Haschek and Rousseaux's Handbook of Toxicologic Pathology


Cuprins

PART 1: Toxicologic Pathology in Product Discovery and Safety Assessment 1. Overview of Drug Development 2. Overview of the Role of Pathology in Product Discovery and Safety Assessment 3. Discovery Toxicology and Pathology 4. Pathology in Non-Clinical Drug Safety Assessment 5. Biopharmaceuticals 6. Biomedical Materials and Devices 7. Carcinogenicity Assessment
PART 2: Safety Assessment and Data Interpretation 8.  Preparation of the Pathology Report for a Toxicology Study 9. Interpretation of Clinical Pathology Results in Non-Clinical Toxicology Testing 10. Statistical Assessment of Toxicologic Pathology Studies 11. Risk Assessment 12. Risk Communication for Toxicologic Pathologists 13. Risk Management in Non-Clinical Drug Development
PART 3: Food and the Environment: Selected Toxic Agents 14. Environmental Toxicologic Pathology and Human Health 15. Food and Toxicologic Pathology: An Overview 16. Nutritional Toxicologic Pathology 17. Endocrine Disruptors 18. Phycotoxins 19. Mycotoxins 20. Selected Poisonous Plants Affecting Animal and Human Health 21. Heavy Metals 22. Agricultural Chemicals 23. Nanoparticulates 24. Radiation and Other Physical Agents


Descriere

Haschek and Rousseaux's Handbook of Toxicologic Pathology, recognized by many as the most authoritative single source of information in the field of toxicologic pathology, has been extensively updated to continue its comprehensive and timely coverage. The fourth edition has been expanded to four separate volumes due to an explosion of information in this field requiring new and updated chapters.
Completely revised with a number of new chapters, Volume 2 encompasses "Toxicologic Pathology in Safety Assessment" and "Environmental Toxicologic Pathology". These two sections cover the application of toxicologic pathology in developing specific product classes, principles of data interpretation for safety assessment, and toxicologic pathology of major classes of environmental toxicants. Other volumes in this work round out the depth and breadth of coverage. Volume 1, "Principles and the Practice of Toxicologic Pathology," covers the practice of toxicologic pathology in three parts: Principles of Toxicologic Pathology, Methods in Toxicologic Pathology, and the Practice of Toxicologic Pathology. Volumes 3 and 4 provide deep and broad treatment of "Target Organ Toxicity", emphasizing the comparative and correlative aspects of normal biology and toxicant-induced dysfunction, principal methods for toxicologic pathology evaluation, and major mechanisms of toxicity. These volumes comprise the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists, and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants. Each volume is being published separately.

 

 

 

  • Provides new chapters on gene therapy, stem cells, regenerative medicine, genome editing, and in-depth discussions of timely topics in toxicologic pathology
  • Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology
  • Features hundreds of full-color images in both the print and electronic versions of the book to highlight difficult concepts with clear illustrations