Dr. David McAllister is a respected medical school professor and heart transplant surgeon with a very ill teen-age patient waiting for a heart. And maybe something more. Over the years several heart transplant patients have shared information about their heart donors that they could not possibly have known. Though the scientist doctor in him rejects such information, he is intrigued by the metaphysical transfers that seem to occur. Is this real or is it just a psychological anomaly? Dr. McAllister begins to wonder that he might be transplanting not only the physical heart, but also a part of the donor's spirit. The race is on to find the right heart and save the teenage girl's life. Heart & Soul explores the amazing metaphysical connections between heart donors and their heart recipients.