High Moon follows the protagonist Finian the vampire and his horse Izzy on a journey a crossed the Wild West. It begins with Finian following a bounty through the deserts of New Mexico. After capturing his intended target: Tommy Two-toothed Talisker, the three are attacked in the desert. The random assault peaks Finian's interest in Tommy. After they return to Jamesonville, a small town that Finian declares as home, it becomes clear that an evil from Finian's past is after Talisker. A few nights later, the town is assaulted and destroyed by magical and mythical creatures. In an attempt to see justice done to those killed in the town, Finian heads after them. As he does, he is attacked in the desert by a new powerful foe. The assault leaves Finian near death and his mighty steed Izzy stolen. Only with the help of some locals does Finian survive and learn that Salt City is where he must go to see this new evil serve justice for the slaughter of Jamesonville and the wickedness forced on the people of Salt City; more importantly though, he would fight to see the return of Izzy.