High Throughput Screening: The Discovery of Bioactive Substances
Autor John P. Devlinen Limba Engleză Hardback – 6 mai 1997
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Specificații
ISBN-13: 9780824700676
ISBN-10: 0824700678
Pagini: 700
Dimensiuni: 178 x 254 x 38 mm
Greutate: 1.27 kg
Ediția:1
Editura: CRC Press
Colecția CRC Press
ISBN-10: 0824700678
Pagini: 700
Dimensiuni: 178 x 254 x 38 mm
Greutate: 1.27 kg
Ediția:1
Editura: CRC Press
Colecția CRC Press
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Public țintă
ProfessionalCuprins
Natural Products as a Discovery Resource, edited by John P. Devlin
Chemical Diversity and Genetic Equity: Synthetic and Naturally Derived Compounds, John P. Devlin
Microcollection of Plants for Biochemical Profiling, John P. Devlin
Enzymes and Microbes as a Source of Chemical Diversity, Saul L. Neidleman
The Marine Environment as a Discovery Resource, Gregg R. Dietzman
Compound Sourcing: Chemically Generated Screening Libraries, edited by Michael R. Pavia
Introduction, Michael R. Pavia
Rapidly Expanding Molecular Diversity: Libraries from Libraries, John S. Kiely, Barbara Dörner, John M. Ostresh, Colette Dooley, and Richard A. Houghten
Synthesis of Encoded Small Molecule Combinatorial Libraries via ECLiPS, Jack J. Baldwin and Ian Henderson
Parallel Organic Synthesis Using Parke-Davis' Diversomer® Method, Sheila Hobbs DeWitt and Anthony W. Czarnik
Rapid Discovery and Optimization of Biologically Active Small Molecules Using Automated Synthesis Methods, Adnan M. M. Mjalli and Barry E. Toyonaga
CMT: A Solution Phase Combinatorial Chemistry Approach: Synthesis and Yield Prediction Phenazines, Ferenc Darvas and László Kovács
Design of a Diverse Screening Library, David E. Patterson, Allan M. Ferguson, Richard D. Cramer, Cheryl D. Garr, Ted L. Underiner, and John R. Peterson
Automating Combinatorial Chemistry: Challenges and Pitfalls, Jill H. Hardin and Frank R. Smietana
Combi-chem High Throughput Screening for Leads Optimization, Richard M. Kris, Patti Willson, Serene Josiah, Marianne Wildgoose, Helen Yeoman, Viktor Krchnak, Stephen Baum, and Stephen Felder
Assay Technologies and Detection Methods, edited by Alfred J. Kolb
Introduction, Alfred J. Koin
Bioassay Design and Implementation, Robert W. Wallace and Mark E. Goldman
Scintillation Proximity Assays, Martino Picardo and Kelvin T. Hughes
FlashPlate™ Technology, Beverly A. Brown, Margaret Cain, Jeff Broadbent, Sharon Tompkins, Georgette Henrich, Rich Joseph, Sally Casto, Harry Harney, Rick Greene, Ron Delmondo, and Simon Ng
Assays for Small Molecule Agonists and Antagonists of the Neurotrophin Receptors, Maureen H. Beresini, Michael D. Sadick, Amy L. Galloway, Randy Yen, Sherry H. Yeh, Andy C. Chang, David L. Shelton, and Wai Lee T. Wong
A Homogeneous, Time-Resolved Fluorescence Method for Drug Discovery, Alfred J. Kolb, Jocelyn W. Burke, and Gerard Mathis
Time-Resolved Fluorometry: Advantages and Potentials, Ilkka Hemmilä
Adaptation of Time-Resolved Fluorescence to Homogeneous Screening Formats, Janet M. Kolb, Greg Yamanaka, and Susan P. Manly
Fluorescence Polarization, J. Richard Sportsman, Sandra K. Lee, Hara Dilley, and Robert Bukar
Reporter Gene Assay Applications, Winfried Scheirer
Development of a Gene Expression-Based Screen Using Quantitative Polymerase Chain Reaction, D. K. H. Lee, E. T. Wilkinson, S. Cheifetz, and S. A. De Grandis
High-Performance Microphysiometry in Drug Discovery, M. Liisa Alajoki, Gregory T. Baxter, William R. Bemiss, David Blau, Luc J. Bousse, Samuel D. H. Chan, Timothy D. Dawes, Karen M. Hahnenberger, James M. Hamilton, Philip Lam, Richard J. McReynolds, Douglas N. Modlin, John C. Owicki, J. Wallace Parce, Dana Redington, Knute Stevenson, H. Garrett Wada, and Jana Williams
Bioanalytical Applications of BIAcore, an Optical Biosensor, Francois Legay, Patrick Albientz, and Rüdiger Ridder
Automation and Robotics, edited by Alfred J. Kolb
Introduction, Alfred J. Kolb
Management and Service Issues of a Centralized Robotic HTS Core, John Babiak
Flexible Use of People and Machines, Mark Beggs and John S. Major
Bar-Code Technology and a Centralized Database: Key Components in a Radioligand Binding Program, Elizabeth A. Kunysz, Melissa Lukes, and Douglas W. Bonhaus
Factors for the Successful Integration of Assays, Equipment, Robotics, and Software, Dejan Bojanic, Wilma W. Keighley, Mike J. Russell, and Terry P. Wood
Accelerating the Discovery Process with Automation and Robotics: A Sure Bet or a Risky Venture?, Richard K. Brown and Andree Proulx
Perspectives on Scheduling, Alain Donzel, Jorge Carmona, and L. Andrew Corkan
Data Retrieval, Handling, and Integration, edited by John P. Devlin
Introduction, John P. Devlin
Database Systems, Barr E. Bauer
Systems Integration, Chip Allee
Data Management and Tracking for Natural Product Programs, Gregg R. Dietzman
Laboratory Design and Management, edited by Matthew A. Sills
Introduction, Matthew A. Sills
Planning and Implementing an HTS Program, Matthew A. Sills and Mark Crawford
Establishing an HTS Program in a Start-up Biotechnology Company, Michael D. Boisclair, James Schultz, and Dan Maloney
Chemical Diversity and Genetic Equity: Synthetic and Naturally Derived Compounds, John P. Devlin
Microcollection of Plants for Biochemical Profiling, John P. Devlin
Enzymes and Microbes as a Source of Chemical Diversity, Saul L. Neidleman
The Marine Environment as a Discovery Resource, Gregg R. Dietzman
Compound Sourcing: Chemically Generated Screening Libraries, edited by Michael R. Pavia
Introduction, Michael R. Pavia
Rapidly Expanding Molecular Diversity: Libraries from Libraries, John S. Kiely, Barbara Dörner, John M. Ostresh, Colette Dooley, and Richard A. Houghten
Synthesis of Encoded Small Molecule Combinatorial Libraries via ECLiPS, Jack J. Baldwin and Ian Henderson
Parallel Organic Synthesis Using Parke-Davis' Diversomer® Method, Sheila Hobbs DeWitt and Anthony W. Czarnik
Rapid Discovery and Optimization of Biologically Active Small Molecules Using Automated Synthesis Methods, Adnan M. M. Mjalli and Barry E. Toyonaga
CMT: A Solution Phase Combinatorial Chemistry Approach: Synthesis and Yield Prediction Phenazines, Ferenc Darvas and László Kovács
Design of a Diverse Screening Library, David E. Patterson, Allan M. Ferguson, Richard D. Cramer, Cheryl D. Garr, Ted L. Underiner, and John R. Peterson
Automating Combinatorial Chemistry: Challenges and Pitfalls, Jill H. Hardin and Frank R. Smietana
Combi-chem High Throughput Screening for Leads Optimization, Richard M. Kris, Patti Willson, Serene Josiah, Marianne Wildgoose, Helen Yeoman, Viktor Krchnak, Stephen Baum, and Stephen Felder
Assay Technologies and Detection Methods, edited by Alfred J. Kolb
Introduction, Alfred J. Koin
Bioassay Design and Implementation, Robert W. Wallace and Mark E. Goldman
Scintillation Proximity Assays, Martino Picardo and Kelvin T. Hughes
FlashPlate™ Technology, Beverly A. Brown, Margaret Cain, Jeff Broadbent, Sharon Tompkins, Georgette Henrich, Rich Joseph, Sally Casto, Harry Harney, Rick Greene, Ron Delmondo, and Simon Ng
Assays for Small Molecule Agonists and Antagonists of the Neurotrophin Receptors, Maureen H. Beresini, Michael D. Sadick, Amy L. Galloway, Randy Yen, Sherry H. Yeh, Andy C. Chang, David L. Shelton, and Wai Lee T. Wong
A Homogeneous, Time-Resolved Fluorescence Method for Drug Discovery, Alfred J. Kolb, Jocelyn W. Burke, and Gerard Mathis
Time-Resolved Fluorometry: Advantages and Potentials, Ilkka Hemmilä
Adaptation of Time-Resolved Fluorescence to Homogeneous Screening Formats, Janet M. Kolb, Greg Yamanaka, and Susan P. Manly
Fluorescence Polarization, J. Richard Sportsman, Sandra K. Lee, Hara Dilley, and Robert Bukar
Reporter Gene Assay Applications, Winfried Scheirer
Development of a Gene Expression-Based Screen Using Quantitative Polymerase Chain Reaction, D. K. H. Lee, E. T. Wilkinson, S. Cheifetz, and S. A. De Grandis
High-Performance Microphysiometry in Drug Discovery, M. Liisa Alajoki, Gregory T. Baxter, William R. Bemiss, David Blau, Luc J. Bousse, Samuel D. H. Chan, Timothy D. Dawes, Karen M. Hahnenberger, James M. Hamilton, Philip Lam, Richard J. McReynolds, Douglas N. Modlin, John C. Owicki, J. Wallace Parce, Dana Redington, Knute Stevenson, H. Garrett Wada, and Jana Williams
Bioanalytical Applications of BIAcore, an Optical Biosensor, Francois Legay, Patrick Albientz, and Rüdiger Ridder
Automation and Robotics, edited by Alfred J. Kolb
Introduction, Alfred J. Kolb
Management and Service Issues of a Centralized Robotic HTS Core, John Babiak
Flexible Use of People and Machines, Mark Beggs and John S. Major
Bar-Code Technology and a Centralized Database: Key Components in a Radioligand Binding Program, Elizabeth A. Kunysz, Melissa Lukes, and Douglas W. Bonhaus
Factors for the Successful Integration of Assays, Equipment, Robotics, and Software, Dejan Bojanic, Wilma W. Keighley, Mike J. Russell, and Terry P. Wood
Accelerating the Discovery Process with Automation and Robotics: A Sure Bet or a Risky Venture?, Richard K. Brown and Andree Proulx
Perspectives on Scheduling, Alain Donzel, Jorge Carmona, and L. Andrew Corkan
Data Retrieval, Handling, and Integration, edited by John P. Devlin
Introduction, John P. Devlin
Database Systems, Barr E. Bauer
Systems Integration, Chip Allee
Data Management and Tracking for Natural Product Programs, Gregg R. Dietzman
Laboratory Design and Management, edited by Matthew A. Sills
Introduction, Matthew A. Sills
Planning and Implementing an HTS Program, Matthew A. Sills and Mark Crawford
Establishing an HTS Program in a Start-up Biotechnology Company, Michael D. Boisclair, James Schultz, and Dan Maloney
Recenzii
"
…a valuable reference.
"-Journal of Pharmacy and Pharmacology
"…a well-referenced, highly professional, comprehensive, and in-depth treatment of a relatively complex approach to the discovery of bioactive substances….
…a recommended book for most private libraries of both academic and industrial pharmaceutical and agricultural chemists and biologists and a must acquisition for applicable and industrial libraries.
"-Journal of Medicinal Chemistry
"…an excellent compendium…covering the breath of current HTS. It will serve as a standard text in the field.
"-Journal of Natural Products
This recommendable book should be of great value for the entry in high throughput screening systems in industry and research. It gives a very useful and clear description of the development of HTS systems from finding resources and generating libraries to assay and detection methods and finally automation, data handling and laboratory design.
- European Journal of Pharmaceutics and Biopharmaceutics, 2000
…a valuable reference.
"-Journal of Pharmacy and Pharmacology
"…a well-referenced, highly professional, comprehensive, and in-depth treatment of a relatively complex approach to the discovery of bioactive substances….
…a recommended book for most private libraries of both academic and industrial pharmaceutical and agricultural chemists and biologists and a must acquisition for applicable and industrial libraries.
"-Journal of Medicinal Chemistry
"…an excellent compendium…covering the breath of current HTS. It will serve as a standard text in the field.
"-Journal of Natural Products
This recommendable book should be of great value for the entry in high throughput screening systems in industry and research. It gives a very useful and clear description of the development of HTS systems from finding resources and generating libraries to assay and detection methods and finally automation, data handling and laboratory design.
- European Journal of Pharmaceutics and Biopharmaceutics, 2000
Descriere
Furnishing the latest interdisciplinary information on the most important and frequently the only investigational system available for discovery programs that address the effects of small molecules on newly discovered enzyme and receptor targets emanating from molecular biology, this timely resource facilitates the transition from classical to high throughput screening (HTS) systems and provides a solid foundation for the implementation and development of HTS in bio-based industries and associated academic environments.