This third part of the AWLAE series on HIV/AIDS and agriculture in sub-Saharan Africa focuses on the epidemic as a challenge to human development in general and rural development in particular. In the face of the impact of the epidemic as described in parts one and two of the series, the agricultural sector can play an important role in mitigating some of its effects. Strategies for agricultural intervention are of particular importance in sub-Saharan Africa, given the fact that most of the countries hardest hit by the epidemic are heavily reliant on agriculture. Different agricultural sector based mitigation strategies are discussed. It is further argued, however, that such interventions need to be complemented by interventions from the health and other sectors, in particular by treatment regimes including access to anti-retroviral drugs. The text is followed by an annotated bibliography.