This report presents a synthesis of historical and current data on HIV epidemiology in the South-East Asia region. It also provides the latest updates on national responses to the epidemic. Individual country profiles summarize the epidemic situation and list key programmatic and data gaps as well as priority actions. The information is presented using graphs with key messages highlighted, making this report useful to a wide audience including HIV program managers in Asia and other countries, policy makers, donors and researchers in the field of HIV/AIDS.