In collaboration with Consulting Editor, Dr. Helen Boucher, Dr. Paul Edward Sax has put together a state-of the-art issue of the Infectious Disease Clinics of North America devoted to HIV. Clinical review articles from expert authors are specifically devoted to the following topics: HIV Diagnostics -- Current Recommendations and Opportunities for Improvement; Update on HIV Prevention -- PreP, PEP, and Other Strategies; Initial Assessment -- What Tests to Order and Why; Why Everyone (Almost) with HIV Needs to be on Treatment -- A Review of the Critical Data; Initial Therapy in the Integrase Inhibitor Era -- Can We Do Better than Two NRTIs plus an INSTI?; Switching Therapy in Patients with Virologic Suppression -- A Why and a How-To Guide; Management of Treatment Failure, With and Without Resistance; Reproduction Options for People with HIV, and Management of Pregnancy; HIV and Addiction - the Role of the ID Clinician; Management of Patients with Advanced HIV Disease - Challenges and Opportunities; HIV and Aging - Focus on Cardiovascular Risk and Metabolic Abnormalities; Key Principles in HIV Pharmacology; One Patient Has Been Cured of HIV - Will There Ever Be More?; and Linkage and Retention in Care - The Keys to Treatment Success. Readers will come away with the latest information they need to manage diagnosis, treatment and outcomes of HIV patients.