Brilliant brothers Langley and Homer Collyer are born into bourgeois New York comfort in settled times, their home a fin-de-siècle mansion on upper Fifth Avenue, their future rosy. But before he is out of his teens Homer begins to lose his sight, Langley returns from the War in Europe with his lungs seared by gas, and when the death of their parents in the influenza epidemic of 1918 leaves the brothers orphaned, they seem perilously ill-equipped to deal with the new era.