The present studies were carried out to observe the effects of mother tinctures of two homeopathic medicines, that is Momoradica charantia and Syzygeum jambolanum. Twenty patients of type 2 (18 males and 2 females) with mean age of 40 years were included in the clinic trials of M. charantia. And twenty patients of types-2 (17 males and 3 females) with mean age of 40 years were included in the clinic trials of S. jambolanum. The blood samples were collected at zero day before the start of trial and after 7, 14, and 21 days of medication. Blood sugar levels were monitored as a function of anti-diabetic effects of these drugs. The results reveal that Momoradica charantia (Karela) no antidiabetic effect and it is the Syzygeum jambolanum (Jamen) which has strong effect where in blood sugar level decreases from 175±3 (mean± sem) mg/dl at zero day to 112±mg/dl at 21 day.