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Hormones, Intrauterine Health and Programming de Jonathan R Seckl

Hormones, Intrauterine Health and Programming: Research and Perspectives in Endocrine Interactions, cartea 12

Editat de Jonathan R Seckl, Yves Christen
en Limba Engleză Hardback – 17 iul 2014
The authors address in particular the role of hormones and their links with other maternal environmental mediators in developmental programming. The crucial nature of the placenta as an interface and target between maternal and foetal environments is addressed. Emphasis is made on the emerging science of epigenetics as a potential explanation for how environmental events that occur during brief windows of development may exert effects that impact upon somatic cells through many rounds of mitosis for much of the life span of the subsequent organism.
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Specificații

ISBN-13: 9783319025902
ISBN-10: 3319025902
Pagini: 189
Ilustrații: XIV, 189 p. 10 illus., 9 illus. in color.
Dimensiuni: 155 x 235 x 17 mm
Greutate: 0.43 kg
Ediția:2014
Editura: Springer International Publishing
Colecția Springer
Seria Research and Perspectives in Endocrine Interactions

Locul publicării:Cham, Switzerland

Public țintă

Research

Cuprins

Foreword.- Early growth and later health: findings from the Helsinki Birth Cohort Study by Johan G. Eriksson.- Male and female placentas have divergent transcriptomic and epigenomic responses to maternal diets: not just hormones by Anne Gabory, Alexandre Vigé, Jean Lesage, Isabelle Fajardy, Laure Ferry, Linda Attig, Anne Vambergue, Didier Vieau, Jean-Philippe Jais, Luc Jouneau, and Claudine Junien.- Glucocorticoids and fetal programming; necessary and sufficient? By Jonathan R. Seckl.- Developmental programming and the placenta: focusing in on glucocorticoids by Caitlin S. Wyrwoll.- Maternal stress and in utero programming by Louise C. Kenny, Claire Everard and Ali S. Khashan.- Developmental epigenetics and risks of later non-communicable disease by M.A. Hanson, P.D. Gluckman  and K.M. Godfrey.- Epigenetic effects of extreme intrauterine growth in humans by John M. Greally.- The Role of the Placenta in Fetal Programming by John Challis, Debora Sloboda, Shaofu Li, Thorsten Braun, Frank Bloomfield, Ghazala Begum, Anne White, Felice Petraglia, John Newnham.- Developmental Origins of Diabetes: The Role of Epigenetics by Rebecca A. Simmons.- Glucocorticoids, programming and the transmission of effects across generations by Amanda J. Drake.- Subject index. ​

Notă biografică

Jonathan Seckl is a Professor of Molecular Medicine at the University of Edinburgh, Endocrinology Unit, Centre for Cardiovascular Science at Queen's Medical Research Institute.

Textul de pe ultima copertă

The environment of the fetus in the womb is emerging as a key determinant not only of its immediate status but also of the offspring’s long-term well-being. This largely started with reports of striking epidemiological associations between lower, but still normal, birth weight and a marked increase in the incidence of cardiac, metabolic and neuropsychiatric disorders from childhood to senescence. In seeking to explain these observations, collectively referred to as ‘developmental programming,’ a new subfield of biology has emerged. Major discoveries include detailing the etiological roles of maternal factors such as nutrition, inflammatory disease, stress and psychopathology. Key biochemical mediators have been discovered, notably including hormones such as glucocorticoids, which act on both the fetus and the placenta to change the trajectory of growth, tissue maturation and the expression of specific genes in affected cells. Such persisting changes in the transcription of genes may be in part underpinned by epigenetic changes. The mechanisms of these effects are beginning to emerge and offer the prospect of new diagnostics, biomarkers and potential therapeutic targets. This work provides an accessible and cutting-edge view of this rapidly emerging field.

Caracteristici

Provides an accessible and cutting-edge view of this rapidly emerging field Explains epidemiological associations between lower birth weight and a marked increase in the incidence of cardiac, metabolic and neuropsychiatric disorders from childhood to senescence Presents the role of hormones and their links with other maternal environmental mediators in developmental programming Includes supplementary material: sn.pub/extras