The research was carried out to gauge the human resource and supply chain management practices, implemented and followed, in the SME sector of Pakistan. SME sector is now in the limelight and Government of Pakistan has taken some serious steps towards the development of this sector. SME policy 2007 is considered as the milestone. Perhaps the SME structure in Pakistan is still fragile and improvements are needed to strengthen this sector. Findings of the study highlighted the level of HR practices and SCM success in SMEs. The integration of these management practices enable SMEs to perform better in the industry and compete in the global markets. This study highlighted the essential HR practices to be carried for better results in supply chain, identified the significant HR functions, and provides a guide for SME owners and managers to utilize their employees in more efficient and effective manner to get the maximum output. The model proposed in this study is designed according to the structure of small and medium sized firms.