These proceedings detail how the TC programme has contributed to the establishment of national nuclear infrastructure and capabilities in Member States over six decades, in support of their national development priorities. The publication also presents examples of successful partnerships and looks to the future regarding appropriate approaches and concrete measures that will help countries to maximize their use of nuclear science and technology in achieving their development goals, including sustainable development goal targets. Key thematic areas covered include the application of nuclear science and technology in human health and nutrition, food and agriculture, water and the environment, radiation technology, energy and safety. Common issues relating to regional collaboration and networking are presented, as is the IAEA and Member States' approach to building lasting and mutually beneficial partnerships.