As human being, when you have been in an exposure to short term cold you might has a flu .But if the cold stay was prolonged in time, as a consequence you may got muscular spasm, abdominal cramps, dairrhoea and /or respiratory problem. Though it is of rare occurrence, at times, cold stay may provokes an inherent, built in immune mechanisms expressed as a response form with a cold acting mediators, the antibodies. These antibodies, in turn forms complexes in presence of complement and epitopes .Such epitopes can be microbial subunit molecules or an auto reactive epitpe .These complexes deposited in the vascular bed of the paranchymatus organs yielding cold induced microscopic and gross lesions .This state is referred to as "Cryoglobulinemia" .The current book is authorized about cryoglobulinemias that are associated with bacterial infections in man and in the simulating animal models .It is intended to be of use for students and researchers of immunology and hematology.