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Infectious Diseases of Humans: Dynamics and Control

Roy M. Anderson, Robert M. May
en Limba Engleză Paperback – 27 aug 1992
This book combines mathematical models with extensive use of epidemiological and other data, to achieve a better understanding of the overall dynamics of populations of pathogens or parasites and their human hosts. The authors thus provide an analytical framework for evaluating public health strategies aimed at controlling or eradicating particular infections. With rising concern for programmes of primary health care against such diseases as measles, malaria, river blindness, sleeping sickness, and schistosomiasis in developing countries, and the advent of HIV/AIDS and other `emerging viruses', such a framework is increasingly important. Throughout, the mathematics is used as a tool for thinking clearly about fundamental and applied problems relating to infectious diseases. The book is divided into two major parts, one dealing with microparasites (viruses, bacteria, and protozoans) and the other with macroparasites (helminths and parasitic arthropods). Each part begins with simple models, developed in a biologically intuitive way, and then goes on to develop more complicated and realistic models as tools for public health planning. A major contribution by two of the leaders in the field, this book synthesizes previous work in this rapidly growing area with much new material, combining work scattered between the ecological and medical literature.
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Specificații

ISBN-13: 9780198540403
ISBN-10: 019854040X
Pagini: 766
Ilustrații: numerous figures and tables
Dimensiuni: 155 x 233 x 43 mm
Greutate: 1.08 kg
Ediția:Revised
Editura: OUP OXFORD
Colecția OUP Oxford
Locul publicării:Oxford, United Kingdom

Cuprins

Preface; Introduction; A framework for discussing the population biology of infectious diseases; Part I: Microparasites: Biology of host-microparasite associations; The basic model: statics; Static aspects of eradication and control; The basic model: dynamics; Dynamic aspects of eradication and control; Beyond the basic model: empirical evidence of inhomogeneous mixing; Age-related transmission rates; Genetic heterogeneity; Social heterogeneity and sexually transmitted diseases; Spatial and other kinds of heterogeneity; Endemic infections in developing countries; Indirectly transmitted microparasites; Part II: Macroparasites: Biology of host-macroparasite associations; The basic model: statics; The basic model: dynamics; Acquired immunity; Heterogeneity within the human community; Indirectly transmitted helminths; Experimental epidemiology; Parasites, genetic variability, and drug resistance; The ecology and genetics of host-parasite associations; Appendices; References; Author index; Subject index

Recenzii

'Senior citizens of the medical profession who are faced with decisions about the direction of future efforts to control disease would do well to read this book, and teachers of courses on public health should find its perspectives invaluable.'The Lancet
'The authors repeatedly stress the importance of keeping the theory in close touch with the facts, and they have pulled together an impressive amount of data that illustrate the value of their mathematical models.'Science
'Aimed at epidemiologists, public health workers, parasitologists, and ecologists and filling a gap between mathematical texts on infectious disease dynamics and texts on epidemiological statistics, [this book] provides the tools for planning and monitoring control programmes ... a major contribution.'British Medical Journal
'... it outlines a comprehensive framework for understanding the population biology of the infectious diseases that cause massive amounts of human suffering and untold economic loss. It is a very important book, lucidly written and exceptionally well organized.'The Higher
'they [do] offer it for review and synthesis and to stimulate interest rather than as a manual for the uninitiated ... In this respect they have succeeded and their work is a major contribution.'Karl G. Nicholson, Senior Lecturer in Infectious Diseases, Leicester, British Medical Journal, Volume 303, 1991
'a convincing, authoritative and important book, and with perseverance has a lot to offer for anyone interested in the epidemiology of infectious diseases'David Isaacs, Immunology & Infectious Diseases, Vol 2, 1992
'The Anderson-May book is a useful compilation of their results and ideas about epidemiological modeling. The authors have effectively blended modelling with data in their analyses of microparasitic and macroparasitic diseases. Their studies of idealized models yield results and concepts which are potentially very useful to epidemiologists and public health decision makers.'Herbert W. Hethcote, University of Iowa, Bulletin of Mathematical Biology, Vol. 55, No. 2, 1993
'The book represents a valiant and monumental effort to bring it all together, and certainly covers a broad range ... the book is replete with graphic and fascinating examples in the epidemiology of infectious diseases, many of which would be suitable for use in teaching ... will prove to be a landmark publication in its field. Its reasonable price will encourage a wide readership.'P. Prociv, The University of Queensland, International Journal for Parasitology, Vol. 23, No. 6
'excellent modern classic'Robin A. Weiss, Nature, Vol. 373, 1994