In this issue of Physical Medicine and Rehabilitation Clinics, guest editors Drs. Joel Stein and Joan Stilling bring their considerable expertise to the topic of Innovations in Stroke Recovery and Rehabilitation. Top experts in the field discuss motor rehabilitation therapies which can be delivered across the acute, subacute, and chronic post-stroke stages; the secondary sequalae of stroke associated with impaired functional outcomes, and much more, helping readers understand the complexities of current stroke rehabilitation techniques and delivery of care.