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Integrated Microfabricated Biodevices: Advanced Technologies for Genomics, Drug Discovery, Bioanalysis, and Clinical Diagnostics de Michael J. Heller

Integrated Microfabricated Biodevices: Advanced Technologies for Genomics, Drug Discovery, Bioanalysis, and Clinical Diagnostics

Editat de Michael J. Heller, Andras Guttman
en Limba Engleză Hardback – 3 ian 2002
This book discusses the new generation of integrated microfabricated devices, including DNA chips, Lab-on-a-Chip, microcapillary electrophoresis systems, biosensors, and microanalytical systems. It traces their development with the established and evolving technologies such as microlithography, micromachining, microelectromechanical systems, microfluids, and nanotechnology.
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Specificații

ISBN-13: 9780824706067
ISBN-10: 0824706064
Pagini: 464
Dimensiuni: 210 x 280 x 26 mm
Greutate: 0.73 kg
Ediția:New.
Editura: CRC Press
Colecția CRC Press

Public țintă

Professional

Cuprins

Towards integrated electrophoretic microdevice for clinical diagnostics; creating a lab-on-a-chip with microfluidic technologies; Short Tandem Repeat (STR) analysis on microfabricated electrophoretic devices; basic sample preparation - DNA separation and purification; multiplex integrated online sample preparation for DNA sequencing and genetic typing; interfacing capillaries to microseparation devices for sample introduction; electric field meditated separation of DNA fragments on planar gel microchips; development of battery powered, portable instrumentation for rapid PCR analysis; practical aspects of sheath flow fraction collection in CE; microelectric array systems for DNA diagnostic and pharmacogenomic applications; the flowthru chip - a miniature, three-dimensional biochip platform; DNA arrays on plastic devices; microfluidic devices fabricated by polymer hot embossing; microfabricated reactor technology; approaches toward miniaturization of high throughput screening of chemical libraries; integrated microsystems in clinical chemistry - constraints and consequences.

Notă biografică

Michael J. Heller, Andras Guttman

Descriere

This interdisciplinary reference discusses the new generation of integrated microfabricated devices, including DNA chips, lab-on-a-chip, microcapillary electrophoresis systems, biosensors, and microanalytical systems, and traces their development with established and evolving technologies. These include microlithography, micromachining, microelectromechanical systems, microfluidics, and nanotechnology. Integrated Microfabricated Biodevices reveals how to reach predetermined locations with proteins and orient molecules while preserving their bioactivity while pinpointing challenges in the effort to automate and integrate miniaturized sample analysis.