Science and technology (S&T) can play an important role in making the economic, environmental and social dimensions of the development process more sustainable. Not only is S&T a key driver of economic growth, but it may also help provide answers for managing resources and reducing pollution, addressing climate change and preserving biodiversity, as well as reducing disease and safeguarding health and well-being, while maintaining the general quality of life. This publication provides the proceedings of an international workshop, held in South Africa, intended to address how international co-operation in science and technology can further the three inter-related aspects (economic, social and environmental) of the development process. The workshop focused on good practices in international S&T partnerships, specifically in the areas of water and energy. In terms of good practices, the workshop examined what works and what doesn't in three areas: 1) enhancing the capacity to absorb technology; (2) transferring technology; and (3) building knowledge networks. In breakout sessions, the workshop identified specific technologies and approaches effective in improving water management and increasing energy efficiency within the varied circumstances of developing countries.