Integration of Metabolism, Energetics, and Signal Transduction: Unifying Foundations in Cell Growth and Death, Cancer, Atherosclerosis, and Alzheimer Disease
Autor Robert K. Ockneren Limba Engleză Hardback – 15 apr 2004
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Specificații
ISBN-13: 9780306484711
ISBN-10: 0306484714
Pagini: 387
Ilustrații: XVII, 387 p. 10 illus., 3 illus. in color.
Dimensiuni: 165 x 248 x 30 mm
Greutate: 0.73 kg
Ediția:2004
Editura: Springer Us
Colecția Springer
Locul publicării:New York, NY, United States
ISBN-10: 0306484714
Pagini: 387
Ilustrații: XVII, 387 p. 10 illus., 3 illus. in color.
Dimensiuni: 165 x 248 x 30 mm
Greutate: 0.73 kg
Ediția:2004
Editura: Springer Us
Colecția Springer
Locul publicării:New York, NY, United States
Public țintă
Professional/practitionerCuprins
Prologue.- Disparate Themes: Origins and Integration.- Fatty Acids, Mitochondria, and Signal Transduction: Integrated Control of Cell Proliferation, Injury, and Death.- to Part II.- Nutrient and Energy Metabolism in Cell Proliferation.- Fatty Acids and Growth Regulation.- Mitochondrial Function in Cell Growth and Death.- Metabolic Effects of Antiproliferative Agents.- Fatty Acids and Mitochondria, Cell Growth and Injury: Broader Implications.- Metabolism and Gene Expression in Liver Regeneration.- II Conclusions.- Fatty Acids, Ketone Bodies, and Brain Metabolism: Implications for Neuronal Function and Alzheimer Disease.- to Part III.- Energetics of Neuronal Activation.- Utilization of Oxidizable Substrates in Brain.- Astrocyte Metabolism and Astrocyte-Neuron Interaction.- Neuronal Energy Metabolism in Brain: Astrocyte as both Metabolic “Buffer” and Mediator of Neuronal Injury.- Pathogenesis of Alzheimer Disease: Metabolic Factors.- III Conclusions.- Epilogue.- Looking Back, Looking Ahead.
Notă biografică
Robert K. Ockner, M.D., Professor of Medicine at the University of California, San Francisco, graduated from Pomona College and Harvard Medical School, and completed clinical and research training at Boston City Hospital, National Institutes of Health, and Massachusetts General Hospital. He is former Director of the UCSF Division of Gastroenterology and the UCSF Liver Center, and served as Editor of Gastroenterology, Co-Editor of Progress in Liver Diseases, and Associate Editor of the Journal of Lipid Research. He and colleagues initially identified and characterized the cytosolic fatty acid binding proteins.
Textul de pe ultima copertă
INTEGRATION OF METABOLISM,
ENERGETICS, AND SIGNAL TRANSDUCTION
Unifying Foundations in Cell Growth and Death, Cancer,
Atherosclerosis, and Alzheimer Disease
ROBERT K. OCKNER
"Dr. Ockner has written a fascinating and original book which explores potential metabolic links to neurodegeneration. He takes a fresh look at metabolic pathways involving interaction between astrocyte and neuron that are important for brain health and may play a significant role in the pathogenesis of Alzheimer disease and other normal and pathological phenomena. Dr. Ockner has a distinguished research career in fatty acid metabolism and the fatty acid binding proteins and writes with clarity upon this under-explored aspect of the brain in health and disease. Not only is his book important for understanding links between systemic and cerebral metabolism in neurodegeneration, but is a must read for scientists with an interest in the connection between metabolic pathways and brain function."
— Dr. Bruce Miller,
Professor of Neurology
Clinical director of the Memory and Aging Center
University of California, San Francisco
"I find this book to be a commendable and comprehensive undertaking as it encompasses an evaluation of a wide area of scientific research. Researchers working in lipid metabolism to those interested in mitochondrial energetics and in the mechanisms of signal transduction pathways in cancer and Alzheimer disease will benefit from this book."
—M.A.Q. Siddiqui,
Professor and Chairman of the Department of Anatomy and Cell Biology
SUNY Downstate, Brooklyn, NY
Robert K. Ockner, M.D. is Professor of Medicine at the University of California, San Francisco, and is former Director of the UCSF Liver Center and Division ofGastroenterology. He and colleagues initially identified and characterized the cytosolic fatty acid binding proteins. He is a graduate of the Harvard Medical School and completed clinical and research training at Boston City Hospital, National Institutes of Health, and Massachusetts General Hospital.
Cover art by Sadie McFarlane
ENERGETICS, AND SIGNAL TRANSDUCTION
Unifying Foundations in Cell Growth and Death, Cancer,
Atherosclerosis, and Alzheimer Disease
ROBERT K. OCKNER
"Dr. Ockner has written a fascinating and original book which explores potential metabolic links to neurodegeneration. He takes a fresh look at metabolic pathways involving interaction between astrocyte and neuron that are important for brain health and may play a significant role in the pathogenesis of Alzheimer disease and other normal and pathological phenomena. Dr. Ockner has a distinguished research career in fatty acid metabolism and the fatty acid binding proteins and writes with clarity upon this under-explored aspect of the brain in health and disease. Not only is his book important for understanding links between systemic and cerebral metabolism in neurodegeneration, but is a must read for scientists with an interest in the connection between metabolic pathways and brain function."
— Dr. Bruce Miller,
Professor of Neurology
Clinical director of the Memory and Aging Center
University of California, San Francisco
"I find this book to be a commendable and comprehensive undertaking as it encompasses an evaluation of a wide area of scientific research. Researchers working in lipid metabolism to those interested in mitochondrial energetics and in the mechanisms of signal transduction pathways in cancer and Alzheimer disease will benefit from this book."
—M.A.Q. Siddiqui,
Professor and Chairman of the Department of Anatomy and Cell Biology
SUNY Downstate, Brooklyn, NY
Robert K. Ockner, M.D. is Professor of Medicine at the University of California, San Francisco, and is former Director of the UCSF Liver Center and Division ofGastroenterology. He and colleagues initially identified and characterized the cytosolic fatty acid binding proteins. He is a graduate of the Harvard Medical School and completed clinical and research training at Boston City Hospital, National Institutes of Health, and Massachusetts General Hospital.
Cover art by Sadie McFarlane