This volume is the proceedings of the sixth General Meeting of the International VLBI Service for Geodesy and Astrometry (IVS), held in Hobart, Tasmania, Australia, February 7-13, 2010. The sixth General Meeting was held in Hobart, Tasmania, Australia on the Sandy Bay Campus of the University of Tasmania. The meeting was hosted by the University of Tasmania, School of Mathematics and Physics, which supports the IVS Network Station at Hobart and is responsible for managing the AuScope project. The keynote of the sixth General Meeting was new perspectives of the next generation VLBI system under the theme "VLBI2010: From Vision to Reality." The vision of the VLBI2010 system is gradually being realized. The unprecedented new capabilities of 1-mm positional accuracy and station velocities of 0.1 mm/yr, continuous observational time series for station positions and Earth orientation parameters, and fast turnaround time from observation to geodetic and astrometric results will foster new science and applications. The goal of the meeting was to provide an interesting and informative program for a wide cross-section of IVS members, including station operators, program managers, and analysts.