This monograph represents an overview of nearly three decades of scientific research by Dr. Lea Cercek and Dr. Boris Cercek. Their research led to the discovery of the human lymphocyte based "SCM Test" for early detection of cancer and to the Cancer Recognition, Immunedefense Suppression and Serine Protease Protection (CRISPP) peptide, a novel cancer marker and a potential target for cancer immunotherapy. It also describes the authors' unfinished research and ideas.