During surveys in 2006, we documented 11 invasive exotic plant taxa at Homestead National Monument of America. Invasive exotic plants occurred in the restored prairies and the forest at the monument. Smooth brome, Osage orange, reed canarygrass, and white mulberry were widespread and abundant. We estimated that each of these plant species covered at least three acres on the monument. Five species occupied less than 0.1 acre. In general, several invasive exotic plants that are difficult to manage are a moderate problem at Homestead National Monument of America, but successful control is possible for a large group of species. The acreage estimates presented in the report may be used to plan management activities leading to control of exotic plants and the accomplishment of GPRA goal IA1b.