Key Clinical Trials in Erectile Dysfunction de Culley C. Carson

Key Clinical Trials in Erectile Dysfunction

Culley C. Carson

This book represents a critical appraisal of the major clinical trials that have had a significant impact on clinical research and practice during the last decade. Each trial follows a strict format, starting with reference to the original source of publication, details on the key investigators and their methods of research. The strengths and weaknesses of each trial are discussed as well as their influence on clinical practice. Articles are complemented by a diagrammatic summary of the trial design and the key findings. It is estimated that over 20 million men in Europe alone suffer at some time in their life from erectile dysfunction (ED). This is the first book to bring together in a single volume a critical review of all the major trials in ED.

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The Earliest Carefully Controlled Clinical Trial Evaluating Oral Pharmacotherapy (Yohimbine) in ED.- A Description of the Pioneering Work That Led to the First Approved Agents for ED: Giles Brindley, the Needle, and the Penis (Phenoxybenzamine).- The Pivotal Study Showing That Intracorporal Injection of Vasoactive Agents (Papaverine or Phenoxybenzamine) Was Effective Pharmacotherapy.- The First Placebo-Controlled Study on the Benefits of Intracorporal Administration of Vasorelaxant Agents to ED Patients (Papaverine/Phentolamine Combination).- Representative Study on the Use of Yohimbine in the Treatment of Organic ED.- Defining the Therapeutic Ratio for Intracavernosal Administration of Prostaglandin E1 (Alprostadil).- An Elegant Long-Term Trial Assessing the Clinical Profile of Intracavernosal Prostaglandin E1 (Alprostadil).- Evaluation of Novel Combination (Vasoactive Intestinal Polypeptide and Phentolamine) as Intracavernosal Therapy.- Now-Classic Study on the Use of Intraurethral Prostaglandin E1 (Alprostadil).- Route of Administration Has a Considerable Impact on Clinical Profile: A Comparison of Intraurethral and Intracavernosal Alprostadil.- First Clinical Data on Sildenafil: The Arrival of Oral Pharmacotherapy.- Original “Gold Standard” Clinical Trial of Sildenafil in ED.- Pilot Study Showing Benefit of Clinical Response to Apomorphine Sublingual (SL).- A Viable Alternative to PDE Inhibitors: Definition of Therapeutic Ratio of Apomorphine Sublingual (SL) in Patients with ED.- Summary of Clinical Trials of Phentolamine.- Impact of Testosterone Replacement in Androgen-Deficient Males.- Evaluation of Psychotherapy for Patients and Partners.- Quantification of Benefit of a Vacuum Device on Erectile Function.- Pioneering Clinical Trial of Surgical Procedures.

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