Key Heterocycle Cores for Designing Multitargeting Molecules
Autor Om Silakarien Limba Engleză Paperback – 14 iun 2018
Adapting the heterocyclic core of a single-target molecule can facilitate its development into an agent capable of acting on multiple targets. Such multi-targeting drugs have the potential to become essential components in the design of novel, holistic treatment plans for complex diseases, making the design of such active agents an increasingly important area of research.
- Emphasizes the chemical development of heterocyclic nuclei, from single to multitargeting molecules
- Provides chapter-by-chapter coverage of the key heterocyclic compounds used in synthesizing multitargeting agents
- Outlines current trends and future developments in multitarget molecule design for the treatment of various diseases
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Specificații
ISBN-13: 9780081020838
ISBN-10: 008102083X
Pagini: 436
Dimensiuni: 152 x 229 mm
Greutate: 0.58 kg
Editura: ELSEVIER SCIENCE
ISBN-10: 008102083X
Pagini: 436
Dimensiuni: 152 x 229 mm
Greutate: 0.58 kg
Editura: ELSEVIER SCIENCE
Public țintă
organic, heterocyclic, computational and medicinal chemists working in both academia and industry, as well as drug discovery researchers in related fieldsCuprins
1. Multitargeting heterocycles – An improved and rational chemical probes for multifactorial diseases 2. Benzimidazole: Journey from a single targeting to a multitargeting nucleus 3. Acridines: A relatively lesser explored heterocycle for multifactorial diseases 4. Flavone: An important scaffold for medicinal chemistry 5. Thiazolidine-2,4-dione: a potential weapon for targeting multiple pathological conditions 6. Oxindole: A nucleus enriched with multi-targeting potential against complex disorders 7. Thiazine: A Versatile Heterocyclic Scaffold for Multifactorial Diseases 8. Indole: As multi-target directed ligands in medicinal chemistry 9. Triazoles: Multidimensional 5-membered nucleus for designing multitargeting agents 10. Benzoxazolinone: A scaffold with diverse pharmacological significance