This technical report is scientifically based technical guidance developed as part of WARRP to provide FEMA with a summary of key response planning factors to consider when responding to a biological incident. Guided by the National Disaster Recovery Framework and the National Preparedness Goals, this document identifies key technical planning areas that may be used to inform subsequent FEMA response and recovery guidance documents. The document employs a scenario narrative focus to describe an example event and provides analysis and recommendations. The overall objective is to provide input to Federal, state, and local planners and decision makers regarding critical areas where planning can significantly improve disaster recovery.