This protocol details the objectives, methods, and data analysis for monitoring landscape changes over time using remote sensing data and technology in the western Great Lakes region of the United States. Detailed methods are in standard operating procedures (SOPs). The protocol involves compiling and processing a time series of Landsat imagery (since 1984) to automate change detection on the landscape using algorithms developed by research scientists at Oregon State University. Collectively, these algorithms comprise a trajectory-based approach known as LandTrendr (Landsat-based detection of trends in disturbance and recovery). The monitoring will take place at Apostle Islands National Lakeshore (APIS), Voyageurs National Park (VOYA), Isle Royale National Park (ISRO), Sleeping Bear Dunes National Lakeshore (SLBE), Pictured Rocks National Lakeshore (PIRO), St. Croix National Scenic Riverway (SACN), Mississippi National River and Recreation Area, and Indiana Dunes National Lakeshore (INDU). This monitoring is funded and conducted by the NPS Great Lakes Inventory and Monitoring Network (GLKN).