Latent Inhibition de Robert Lubow

Latent Inhibition: Cognition, Neuroscience and Applications to Schizophrenia

Robert Lubow

Ina Weiner

Latent inhibition is a phenomenon by which exposure to an irrelevant stimulus impedes the acquisition or expression of conditioned associations with that stimulus. Latent inhibition, an integral part of the learning process, is observed in many species. This comprehensive collection of studies of latent inhibition, from a variety of disciplines including behavioural/cognitive psychology, neuroscience and genetics, focuses on abnormal latent inhibition effects in schizophrenic patients and schizotypal normals. Amongst other things, the book addresses questions such as, is latent inhibition an acquisition or performance deficit? What is the relationship of latent inhibition to habituation, extinction, and learned irrelevance? Does reduced latent inhibition predict creativity? What are the neural substrates, pharmacology, and genetics of latent inhibition? What do latent inhibition research and theories tell us about schizophrenia? This book provides a single point of reference for neuroscience researchers, graduate students, and professionals, such as psychologists and psychiatrists.

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Cuprins

Preface R. E. Lubow and Ina Weiner; 1. A short history of latent inhibition research R. E. Lubow; Part I. Behaviour and Cognition: 2. Latent inhibition and extinction: their signature phenomena and the role of error correction R. F. Westbrook and M. E. Bouton; 3. Inter-stage context and time as determinants of latent inhibition G. L. De la Casa and Oskar Pineno; 4. Latent inhibition: acquisition or performance deficit? Martha Escobar and Ralph Miller; 5. Latent inhibition and learned irrelevance in human contingency learning M. E. LePelley and Mia Schmidt-Hansen; 6. Associative and non-associative processes in latent inhibition: an elaboration of the Pearce-Hall model Geoffrey Hall and G. Rodriguez; 7. From latent inhibition to retrospective reevaluation learning: an attentional-associative model Nestor Schmajuk; 8. Latent inhibition and habituation: evaluation of an associative analysis R. C. Honey, M. Iordanova and M. Good; 9. Latent inhibition and creativity Shelley Carson; Part II. Neurobiology: 10. The phylogenetic distribution of latent inhibition R. E. Lubow; 11. The genetic component of latent inhibition: studies of inbred and mutant mice Tatiana Lipina and John Roder; 12. A comparison of mechanisms underlying the CS-US Association and the CS-Nothing Association T. Gould; 13. The pharmacology of latent inhibition and its relevance to schizophrenia Ina Weiner and M. Arad; 14. Parahippocampal region-dopaminergic neuron relationships in latent inhibition A. Louilot, J. Jeanblanc, Y. Peterschmitt and F. Meyer; 15. Latent inhibition and other effects from salience modulation: do they share the same neural substrates? Helen Cassaday and Paul Moran; 16. What the brain teaches us about latent inhibition (LI): the neural substrates of the expression and prevention of LI Ina Weiner; Part III. Latent Inhibition and Schizophrenia: 17. Latent inhibition in schizophrenia and schizotypy: a review of the empirical literature Veena Kumari and Ulrich Ettinger; 18. A cautionary note about latent inhibition in schizophrenia: are we ignoring relevant information? Neil Swerdlow; 19. Latent inhibition as a function of anxiety and stress: implications for schizophrenia Hedva Braunstein-Bercovitz; 20. Nicotinic modulation of attentional deficits in schizophrenia Paul Schnur and Allison Hoffman; 21. Latent inhibition and schizophrenia: the ins and outs of context R. E. Lubow; 22. Summary and conclusions: some unresolved and controversial issues in latent inhibition research and theory R. E. Lubow and Ina Weiner.