Science is at a cross-roads. For several decades, the Standard Model of particle physics has managed to fit vast amounts of particle scattering data remarkably well, but many questions remain. During those decades, some sophisticated theoretical hypotheses such as string theory, quantum gravity, and quantum cosmology have been proposed and studied intensively, in an effort to break the log-jam of the Standard Model. None of those hypotheses have succeeded to date. Of greater concern is the increasing tendency by some practitioners in those fields to downplay the empirical principles of science. In response, this book is a restatement of those principles, covering numerous aspects of observation. A particular focus is on contextuality versus realism, the two fundamentally contrasting ideologies that underpin modern physics.