This volume contains contributions to the XXI International Symposium on Lepton and Photon Interactions at High Energies, held at the Fermi National Accelerator Laboratory. It gives up-to-date reviews of all aspects of particle physics, written by leading practitioners in the field. The review nature of all the articles makes this volume more accessible to students and researchers in other fields of physics. In addition to new experimental data and advances in theory, the future directions and prospects for the field are covered.The proceedings have been selected for coverage in: • Index to Scientific & Technical Proceedings® (ISTP® / ISI Proceedings)• Index to Scientific & Technical Proceedings (ISTP CDROM version / ISI Proceedings)• CC Proceedings — Engineering & Physical Sciences