When a gray kitten named Jane is cruelly cast on the street at ten weeks old, she spends her time hiding in bushes and under porches, terrified of dangers around her. Hungry and cold, she finally meets a kind opossum who leads her around the neighborhood to yummy morsels of food. The odd duo stick together until fate shines upon Jane. Plucked from the clutches of street life, Jane is adopted into a loving home and makes a friend for life in the family's dog, a Labrador retriever named Danny Lunder. She is content, warm, and safe, and so writes heartfelt letters to her mother describing her life and good fortune, hoping to relieve any her mother's fears. But the man and woman of the family are elderly and before long, after a series of accidents, Jane ends up on the street again, and Danny finds a home with another master. This time, Jane writes to Danny, unaware of his new circumstances but desperately wanting to reconnect with her old friend. Despair tries to ensnare her once more, but she fights it desperately. After all, now she has more than herself to look after: she is expecting kittens. "Letters from Jane" offers a thoughtful, engaging tale of life as experienced through an animal's eyes.