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Life-Threatening Effects of Antipsychotic Drugs

Editat de Peter Manu, Robert J. Flanagan, Kathlyn J. Ronaldson
en Limba Engleză Hardback – 15 aug 2016
Life-Threatening Effects of Antipsychotic Drugs describes in detail more than 20 life-threatening effects associated with antipsychotics, presents the best available data on their incidence and case fatality, and gives comprehensive advice on diagnosis, management and preventive strategies. In addition, the book discusses the benefit of antipsychotic medication in a range of therapeutic indications, and demonstrates the gain in life-expectancy associated with clozapine use in severe mental illness despite its serious, potentially life-threatening adverse effects.


  • Covers cardiovascular, neurological, muscular, hematological, gastrointestinal, autonomic and metabolic effects
  • Gives advice on risk factors, confounding diagnoses and measures to minimise seriousness
  • Discusses clozapine rechallenge after each of its serious adverse reactions
  • Makes suggestions for optimum management of somatic disease in those with severe mental illness, to improve life-expectancy
  • Includes data on post-mortem considerations
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Specificații

ISBN-13: 9780128033760
ISBN-10: 0128033762
Pagini: 394
Dimensiuni: 152 x 229 x 37 mm
Greutate: 0.75 kg
Editura: ELSEVIER SCIENCE

Cuprins

Part I: Cardiovascular Adverse Effects of Antipsychotic Drugs
Chapter 1 - Sudden Cardiac Death and Ventricular Arrhythmias
Peter Manu, Anca Dan and Gheorghe-Andrei Dan
Chapter 2 - Myocarditis and Cardiomyopathy
Kathlyn J. Ronaldson
Chapter 3 - Pulmonary Embolism
Peter Manu, Christopher Hohman, James F. Barrecchia, and Matisyahu Shulman
Chapter 4 - Orthostatic Hypotension
James J. Gugger and Megan J. Ehret
Part II: Hematological Complications of Treatment With Antipsychotic Drugs
Chapter 5 - Severe Neutropenia and Agranulocytosis
John Lally and Robert J. Flanagan
Part III: Antipsychotic-Related Pathology of the Digestive System
Chapter 6 - Gastrointestinal Hypomotility and Dysphagia
Robert J. Flanagan and Kathlyn J. Ronaldson
Chapter 7 - Liver Failure
Katie F.M. Marwick
8. Pancreatitis
Peter Manu, Matisyahu Shulman and Kathlyn J. Ronaldson
Part IV: Major Neurological and Neuromuscular Adverse Effects of Antipsychotic Drugs
Chapter 9 - Seizures
Tilman Steinert and Walter Fröscher
Chapter 10 - Neuroleptic Malignant Syndrome
Julie Langan Martin and Daniel J. Martin
Chapter 11 - Heat Stroke and Rhabdomyolysis
Kathlyn J. Ronaldson
Part V: Metabolic Complications of Antipsychotic Drug Treatment
Chapter 12 - Type 2 Diabetes Mellitus
Davy Vancampfort, Richard I.G. Holt, Brendon Stubbs, Marc De Hert, Katherine Samaras and Alex J. Mitchell
Part VI: Other Life-Threatening Effects of Antipsychotic Drugs
Chapter 13 - Interstitial Nephritis and Interstitial Lung Disease
Kathlyn J. Ronaldson
Part VII: Clinical and Forensic Challenges in the Use of Antipsychotic Drugs
Chapter 14 - The Benefits of Antipsychotic Drugs: Symptom Control and Improved Quality of Life
Jian-Ping Zhang
Chapter 15 - Antipsychotic-Related Mortality: Risk and Strategy for Improved Clinical Management
Dan Cohen
Chapter 16 - Forensic Investigation of Antipsychotic-Related Deaths
Robert J. Flanagan and Peter Manu

Recenzii

"… this book …presents important evidence-based information on side effects of antipsychotic drugs and how to prevent and counteract these. The book is organized in seven parts, all of them dealing with adverse effects of antipsychotic drugs in different organ systems: cardiovascular adverse effects, haematological complications, the digestive system, neurological and neuromuscular, metabolic complications, other life-threatening effects such as interstitial diseases in kidney and lung and, finally, a chapter dealing with clinical and forensic challenges in the use of antipsychotic drugs.
All subjects are treated in a consistent manner, starting with an epidemiological overview, followed by some background regarding pathobiology, continuing over clinical signs to management, ending up with suggestions for prevention of the conditions. The book has a richness of tables and figures facilitating the reading and understanding of the book’s important information and many messages of, e.g. Hazard ratios, odds ratios, clinical algorithms, all making it easily accessible.
… The book is highly relevant to the clinically working psychiatrist, his/her assistants, medical students and other with interest in the interphase between psychiatric illnesses, somatic diseases, their treatment and the always present balance between effect and side effects of treatments." --Mikkel Hojlund, Povl Munk-Jørgensen, Nordic Journal of Psychiatry