A new compounds of 2,4-substituted-1,3- thiazole containing amines I] and II], Schiff bases IV] and V], amides VI]- X], esters XI] - XIII], thiazolidinones XIV]- XVIII] and 1,3-oxazepines XIX]- XXV] were Synthesized and characterized by melting points, FTIR spectroscopy, elemental analysis, 1HNMR,13CNMR, dept135and Mass spectroscopy. The liquid crystalline properties of the synthesized compounds were verified by using hot-stage polarizing optical microscopy (POM) and differential scanning calorimeter (DSC). The compound I] was found to be nematic textures (N). The first series of this study II]n display only enantiotropic nematic phase when n=1-5 while the compounds with n =6-8 display two mesophasese smectic C(SmC) and nematic phases(N). All compounds of series IV]n were found to be enantiotropic nematic phase. Compounds VI]a and VI]b showed both semctic and nematic phases. Compounds XI]a, b and XIII]a, b showed only nematic texture but the compounds XI]c and XIII]c did not show any liquid crystalline properties. All compounds of series XVII]n with n=1,3-7 display only nematic texture but compound with n=8 showed semactic C phase (SmC) in addition of n