Approaching the topic from a patient-centered perspective and focusing on what is clinically relevant, this continually-updated website explores drug interactions to help reduce harmful polypharmacy. It includes prescription and over-the-counter drugs as well as biologics, supplements, and other medical products—with tens of thousands of adverse drug reactions, eruptions, and reaction patterns. It provides a summary of the evidence base for the reactions, allowing practitioners to assess risk, and includes products such fillers and toxins, making it useful to dermatologists who have expanded into cosmetic practice.