Dr. Lefkowitch has created a primer on liver pathology for the gastroenterologist that provides depth of clinical coverage in an area not typically covered in depth for gastroenterologists. This issue will provide state-of-the-art reviews in the areas of NAFLD, liver biopsy, liver pathology, hepatitis, and genomics. Articles are specifically devoted to IgG4-related disease and the liver; current concepts in pediatric NAFLD; evaluation of the pediatric liver biopsy; hepatocellular adenomas: morphology and genomics; drug-induced liver injury: the hepatic pathologist's approach; liver pathology in alpha-1-antitrypsin deficiency; immunohistochemistry in the diagnosis of hepatocellular carcinoma; HIV infection, antiretroviral therapy and liver pathology; autoimmune hepatitis overlap syndromes and liver pathology; current perspectives on the pathology of hepatocellular carcinoma and its variants; hepatitis E virus and the liver: clinical settings and liver pathology; hepatic progenitor cells; and cholangiocarcinoma: current genomics and pathology, to name a few.