"Local Responses to Global Challenges in Southeast Asia - A Transregional Studies Reader" is a collection of multidisciplinary essays, predominantly derived from papers presented at EuroSEAS 2019, the leading academic conference on Southeast Asian Studies, hosted by Humboldt-Universität zu Berlin. It brings together a variety of scholars from Southeast Asia, Europe and North America, allowing for multiple flows and directionalities of knowledge productions and exchanges, be it between the Global South and North as well as within the Global South. The reader presents empirically-oriented, theoretically grounded analyses of local responses to global challenges such as knowledge-productions; notions and practices of building diverse communities; neo-populisms and contentious politics; resources and sustainability; urbanization; labor, livelihoods and mobilities. Each section starts with an introduction reviewing the state of the art. Authors will take cue from a transregional perspective understood as a distinct and alternative perspective on multi-lingual and transcultural spaces of contact, exchange and transfer. This includes a contextualization of phenomena in terms of diverse (cross) linkages and entanglements, including motilities on different scales, i.e. ranging from the local, regional to national and/or global levels. Container-based notions of place and space are addressed in a critical manner, where space and area are understood as notions beyond established systems of ordering and meta-geographies. A key goal is to allow for a consistent conceptual advancement of New Area Studies, which are critical, decentred, decolonial, diversified, and multi-disciplinary in nature.