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Long Circulating Liposomes: Old Drugs, New Therapeutics: Biotechnology Intelligence Unit

Editat de Martin C. Woodle, Gerrit Storm
en Limba Engleză Paperback – 13 noi 2013
This book provides an up-to-date evaluation of clinical aspects of newly available "long-circulating liposome" formulations. Based on results from numerous clinical studies, the book describes the fundamentals of this new technology, discusses how it may influence the pharmacology of existing well-known agents reformulated in this manner, and elaborates on future expectations. It provides the practicing clinician - in particular, oncologists and critical care infectious disease physicians - with the tools needed to use these new formulations towards the best outcome for the patient.
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Specificații

ISBN-13: 9783662221174
ISBN-10: 3662221179
Pagini: 324
Ilustrații: XX, 301 p. 34 illus.
Dimensiuni: 155 x 235 x 17 mm
Greutate: 0.45 kg
Ediția:Softcover reprint of the original 1st ed. 1998
Editura: Springer Berlin, Heidelberg
Colecția Springer
Seria Biotechnology Intelligence Unit

Locul publicării:Berlin, Heidelberg, Germany

Public țintă

Professional/practitioner

Cuprins

1. Long Circulating Liposome Therapeutics: From Concept to Clinical Reality.- 2. Oncologic Agents in Sterically Stabilized Liposomes: Basic Considerations.- 3. Liposomal Vincristine: The Central Role of Drug Retention in Defining Therapeutically Optimized Anticancer Formulations.- 4. Long Circulating Liposome-Encapsulated Tumor Necrosis Factor in the Treatment of Solid Tumors.- 5. Therapy of Human Carcinoma Xenografts with Doxorubicin Encapsulated in Sterically Stabilized Liposomes (DOXIL®): Efficacy and Safety Studies.- 6. Design and Development of Long Circulating Liposomal Daunorubicin for In Vivo Targeting of Solid Tumors: DaunoXome®.- 7. Enhancement of Doxorubicin by Encapsulation in Long circulating Thermosensitive Liposomes Combined with Local Hyperthermia.- 8. Liposomal Localization and Chemotherapy for AIDS-Related Kaposi’s Sarcoma.- 9. Pegylated-Liposomal Doxorubicin (Doxil®) in the Treatment of AIDS-Related Kaposi’s Sarcoma.- 10. DaunoXome® (Liposomal Daunorubicin) for First-Line Treatment of Advanced, HIV-Related Kaposi’s Sarcoma.- 11. Initial Clinical Evaluation of Pegylated-Liposomal Doxorubicin in Solid Tumors.- 12. Antibacterial Therapy with Sterically Stabilized Liposome Formulations.- 13. AmBisome®: Long Circulating Liposomal Formulation of Amphotericin B.- 14. Steric Stabilization of Liposomes Containing Amphotericin B: A Future Direction in Antifungal Therapy?.- 15. Clinical and Preclinical Studies with Low-Clearance Liposomal Amikacin (MiKasome®).- 16. Sterically Stabilized Liposomes to Image Infection and Inflammation.- 17. Long Circulating Liposomes for Diagnostic Imaging.- 18. Tumor Imaging with Long Circulating Liposomes.- 19. Antibody-Mediated Targeting of PEG-Coated Liposomes.- 20. Small Molecule Ligands for Targeting LongCirculating Liposomes.