Parkinson’s Disease is a complex disease that affects millions of patients worldwide. Lysosomal pathophysiology has become an emerging key to better understanding the progression of Parkinson’s Disease. Lysosomal Pathophysiology of Parkinson’s Disease introduces how genetic and genomic insights shape the molecular view on Parkinson’s Disease. Specifically, this book presents data on the involvement of the autophagy-lysosome pathway in pathogenic processes. This book draws a timeline of disease onset and progression by examining the impact of autophagy-lysosome function to include other mechanisms and how to link these stages using the molecular lens. In addition, chapters will compare this example in Parkinson’s disease to other neurodegenerative diseases characterized by protein pathology and synaptic alterations, such as Alzheimer’s disease and Frontotemporal Dementia.

• Provides a molecular view of Parkinson’s Disease
• Identifies the pathogenic impact of the autophagy-lysosome pathway
• Measures disease progression relative to lysosomal pathophysiology
• Compares protein pathology and synaptic alterations across neurodegenerative diseases