This last volume of the Karlsruhe Papers on Economic Policy Research, edited by Rolf Funck and Werner Rothengatter, focuses on the interactions between man, environment, space and time, following the holistic research approach of Walter Isard which initiated a re-orientation of regional science. New research tracks were opened in all four dimensions and long before Paul Krugman's New Economic Geography the importance of space was emphasized in an economic environment of monopolistic competition, increasing returns to scale and increasing scarcity of natural and environmental resources. The 22 articles of internationally renowned authors in this volume start from this basis and present in-depth research approaches in all four dimensions. With contributions by: David Boyce; Rolf Funck; Nicholas Balabkins; Tatsuhiko Kawashima, Noriyuki Hiraoka and Junichi Noro; Antonio Musso and Maria Vittoria Corazza; Daniela-Luminita Constantin; Yoshitsugu Hayashi; Axel Schaffer and David Moellendorf; Marc Gaudry and Emile Quinet; Soushi Susuki and Peter Nijkamp; Jan S. Kowalski and Mirja Meyburg; Kay Mitusch, Gernot Liedtke, Laurent Guihery and David Balz; Werner Rothengatter; Haixiao Pan and Jian Haiyun; Hilde Meersman and Eddy van de Voorde; Roger Vickerman; Tim Deeken and Ingrid Ott; Ryszard Domanski; Ulrich Blum; Dieter Bokemann; Riccardo Cappellin