The United States is developing a unified strategy to manage Maritime Security. The task requires coordination of a number of U.S. Government agencies and coalition partners. The Maritime Operational Threat Response plan is designed to coordinate the response across the multiple agencies. Coordination of the response to a Maritime Operational Threat is done via virtual collaboration across the MOTR agencies. This organizational arrangement is less than optimal. The United States requires a single operational command center to synthesis, coordinate, and direct the operational response to threats in the Maritime Domain. This paper describes the advantages of a Maritime Operational Threat Response Center to coordinate the response to threats from the Maritime Domain.