The relationship between type 2 diabetes (T2D) and osteoporosis (OP) was less clear. Also and did not affect prognosis OP in postmenopausal women in Thi-Qar governorate in the south of Iraq with T2D and the cause for the development of OP. Insulin and metformin therapy, one of the anti-hyperglycemic agents, commonly used for T2D, but unclear their influence the development of OP in postmenopausal women.