MATLAB is a useful tool for computer specialists. Economists also should be assisted by computer specialists or benefit from computer software package. However, computer specialists can not solve complicated economic problems because of the lack of in-depth of understanding of economics. This book aims to provide technical reference for the regional economists and the regional economy workers to master MATLAB. Conceptual framework for regional economic decision-making problems is presented in the book, and MATLAB-based solutions and technical details. It is possible to get through the regional economy, the concept and the technology gap between fuzzy mathematics and MATLAB. The book is to try to make a regional economist master MATLAB tools in a relaxed atmosphere. Therefore, it simplifies off all unnecessary programming content. Meanwhile, in order to enable the reader to the creative application of MATLAB, the book discusses the main aspects of the actual problems of the regional economic decisions, which will help regional economists improve their projects based on the application of MATLAB.