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Medicinal Chemistry and Drug Development

Editat de Gang Liu
en Limba Engleză Paperback – 17 feb 2025
Medicinal Chemistry and Drug Development describes the key events and roles of medicinal chemistry in the discovery and development of lead compounds into drugs (including target identification). In 30 case studies, the book covers all stages of drug development, including the discovery of active compounds, research on the pharmacological properties of molecules, and confirmation of drug targets.

  • Provides unique information on different drug development case studies
  • Integrates pharmaceutical knowledge—mainly medicinal chemistry—with new drug development thinking
  • Describes the impact of key events in drug development and drug efficacy using case studies
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Specificații

ISBN-13: 9780443274022
ISBN-10: 0443274029
Pagini: 800
Dimensiuni: 152 x 229 mm
Greutate: 0.45 kg
Editura: ELSEVIER SCIENCE

Cuprins

1. Medicinal chemistry and product process development of Sitagliptin, a drug for anti type 2 Diabetes. 2. Insulin
3. GLP-1 receptor agonist for drug development
4. Antidiabetic drugs development based on sodium-glucose cotransporter 2 (SGLT2) inhibitors: Dapagliflozin
5. Atorvastatin, a cholesterol-reducing drug
6. Discovery of Angiotensin II receptor blockers for hypertension: Losartan and its analogues
7. Apixaban, an antithrombotic drug for thrombosis
8. Fondaparinux, an anticoagulant drug
9. Development of Sofosbuvir, an antiviral nucleoside for HCV
10. Discovery and development of Raltegravir, the first HIV-1 integrase inhibitor
11. Discovery and development of Saquinavir, an HIV protease inhibitor
12. Baloxavir Marboxil, a novel anti-influenza drug
13. Taxol, a natural antitumor drug
14. Eltrombopag, an natural derivative of antitumor drug
15. Imatinib, a tyrosine kinase inhibitor for cancer treatment
16. Afatinib, an irreversible covalent EGFR inhibitor for cancer treatment
17. Tamoxifen, an anticancer drug for breast cancer
18. Fluconazole, a triazole antifungal drug
19. Linaclotide, an oxazolidinone class antibacterial drug
20. Meropenema carbapenem class antibacterial drug
21. Antiparasitic drug pyrroloquinoline quinone
22. Proton pump inhibitor Omeprazole
23. Discovery of PDE5 inhibitors for the treatment of erectile dysfunction and pulmonary arterial hypertension
24. GABAA receptor agonists: discovery of the general anesthetic Propofol and its analogs
25. Discovery of multitarget drug Risperidone
26. First ani-renal anemia drug Roxadustat
27. The splendid transformation process of a natural product: function, medicinal research, and development process of natural (+)-Calanolide A
28. Bone-specific targeted drug Bisphosphonate
29. Selective COX-2 inhibitor Celecoxib
30. Examples of antisense nucleotide drugs for the treatment of Duchenne muscular dystrophy