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Medicinal Chemistry of Chemotherapeutic Agents: A Comprehensive Resource of Anti-infective and Anti-cancer Drugs

Editat de Pratap Chandra Acharya, Michio Kurosu
en Limba Engleză Paperback – 13 mar 2023
Medicinal Chemistry of Chemotherapeutic Agents: A Comprehensive Resource of Anti-infective and Anti-cancer Drugs focuses on the basics and fundamentals of chemistry involved in chemotherapeutic agents. Each chapter comprises distinct chemical classifications that include structure and IUPAC nomenclature, synthetic schemes and routes for each drug, mechanism of the drug action, metabolic pathway and structure–activity relationship (SAR) studies. The book covers current research focused on drug resistance and methods to overcome it, the development of newer drugs belonging to each category of the chemotherapeutic agents, molecules currently under clinical trials, and newly approved drugs, if any.
This book will be a valuable resource for academics and researchers, helping them to understand the fundamentals of the medicinal chemistry of the chemotherapeutic agents.


  • Includes current research focused on drug resistance and methods to overcome problems
  • Outlines synthetic schemes and metabolic pathways of chemotherapeutic agents
  • Discusses molecules under clinical trials and newly approved drugs
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Specificații

ISBN-13: 9780323905756
ISBN-10: 0323905757
Pagini: 686
Ilustrații: Approx. 100 illustrations (100 in full color)
Dimensiuni: 216 x 276 x 37 mm
Greutate: 1.79 kg
Editura: ELSEVIER SCIENCE

Cuprins

1. Introduction to Chemotherapy: General and Clinical Considerations
Section A. ANTIMICROBIAL AGENTS
Unit I Antibacterial Agents
2. Sulfonamides, Quinolones, Antiseptics and Disinfectants
Unit II Antibacterial Antibiotics
3. Beta-Lactam Antibiotics: Penicillins, Cephalosporins, Monobactams, Carbapenems and Beta-lactamase Inhibitors
4. Tetracyclines and Chloramphenicol
5. Aminoglycoside Antibiotics
6. Macrolide, Lincosamide, Glycopeptide and Other Antibacterial Antibiotics
Unit III Antimycobacterial Agents
7. Antitubercular Drugs
8. Antileprotic Drugs
Unit IV Antifungal Agents
9. Topical and Systemic Antifungal Drugs
Unit V Antiviral Agents
10. Antiviral Drugs and Vaccines
Unit VI Antiprotozoal Agents
11. Antimalarial Drugs
12. Antiamoebic Drugs
13. Drugs for Giardiasis, Trichomoniasis and Leishmaniasis
UNIT VII Anthelmintics
14. Vermifuge and Vermicide Drugs
Section B ANTINEOPLASTIC AGENTS
15. Synthetic Cytotoxic Drugs as Cancer Chemotherapeutic Agents
16. Naturally Occurring Anticancer Cytotoxic Drugs
17. Hormones and Antihormones in Cancer Chemotherapy
18. Biologicals and Small Molecules as Target Specific Cancer Chemotherapeutic Agents

Recenzii

“...covers the wide body of medicinal chemistry behind modern anti-infective and anti-neoplastic agents in an engaging manner. Each chapter opens with a well-written exposition on the history, relevance, and current issues at play in the drug category before delving deep into synthesis, general structure, structure-activity relationship (SAR), natural origins, synthetic derivatives, and ongoing research. The book makes intelligent and logical use of figures and tables to organize and illustrate the information,…[with] a level of depth appropriate for its complexity. [A] worthwhile addition.... [that] exquisitely details the mechanism of action, synthesis, SAR, and relation to the modern world for each drug category…[with] additional pearls on relevant disease pathophysiology or evolution of agent resistance throughout…. [A] useful book for multiple disciplines, including the larger range of researchers and health professionals who work directly with infectious or malignant diseases.” --©Doody’s Review Service, 2023, Forrest N Ridgway, PharmD (Temple University Health System)