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Medicinal Chemistry de Norma K Dunlap

Medicinal Chemistry

Autor Norma K Dunlap, Donna M Huryn
en Limba Engleză Paperback – 17 apr 2018
Medicinal Chemistry teaches essential concepts by focusing on how the field is actually practiced, melding real-world research experience with basic principles and modern methods. Written by practicing medicinal chemists, this textbook is intended for advanced undergraduates and first-year graduate students in biology, chemistry, and biochemistry.  Pre-medical or pre-pharmacy students and professionals entering the drug discovery field will also find it a useful reference.  Building on a foundation of synthetic organic chemistry and structural biology, the book interweaves therapeutics, case studies, historical context, and techniques for discovering, developing, and optimizing new drugs. Chapters are richly illustrated and include problems and annotated journal references with accompanying exercises and answers.
  • Authored by practicing medicinal chemists—melding real-world research experience with basic concepts and up-to-date methods
  • Flexible in presentation— the first five chapters provide a conceptual foundation and historical understanding of the field; subsequent chapters explore the application of concepts. Chapters can be assigned in order of instructor preference and desired emphasis
  • Presents easy-to-follow tables and descriptions of assays next to their relevance to medicinal chemistry and drug discovery, along with target values—information rarely found all in one place, but is a crucial reference
  • Case studies and Journal Club use current literature to apply concepts from the text to real-life examples. They are also suitable for flipped classrooms and self-study
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Specificații

ISBN-13: 9780815345565
ISBN-10: 0815345569
Pagini: 508
Ilustrații: 588 Illustrations, color
Dimensiuni: 210 x 280 x 30 mm
Greutate: 1.17 kg
Ediția:1
Editura: CRC Press
Colecția Garland Science
Locul publicării:Boca Raton, United States

Cuprins

PART I: Drug Discovery and Development  1. Historical Perspective and Overview of Drug Discovery  2. Drug discovery: Hit and Lead Discovery  3. Drug Discovery: Optimization of Lead Properties  PART II: Classes of Drug Targets  4. Medicinal Chemistry Strategies Used in Lead Optimization  5. The Process of Developing a Drug from an Optimized Lead  6. Receptors as Drug Targets  7. Enzymes as Drug Targets  8. Protein-Protein Interactions and Lipids as Drug Targets  9. DNA and RNA as Drug Targets  PART III: Selected Therapeutic Areas  10. Anti-Cancer Drugs  11. Infectious Diseases I: Antiviral and Antifungal Drugs  12. Infectious Diseases II: Antibacterial and Antiparasitic Drugs  13. Drugs Acting on the CNS

Notă biografică

Norma Dunlap is Professor of Chemistry at Middle Tennessee State University, where she specializes in synthetic organic chemistry and medicinal chemistry. Her research interests include the design and synthesis of bioactive compounds, as well as isolation, identification, and synthesis of bioactive natural products. She holds a PhD in Organic Chemistry from the University of Wyoming and was an NIH Postdoctoral Fellow at the University of Pennsylvania. Prior to an academic career, she was a Senior Research Scientist in drug discovery at Hoffmann-LaRoche.Donna M. Huryn is Research Professor in the Department of Pharmaceutical Sciences at the University of Pittsburgh and Adjunct Professor of Chemistry at the University of Pennsylvania and. Her research focuses on identi_cation, characterization, and optimization of small molecule probes and drugs to treat cancer, neurodegeneration and infectious diseases. She holds a PhD from the University of Pennsylvania and started her career as a medicinal chemist in the pharmaceutical industry. She is the Principal Investigator of the University of Pittsburgh Chemical Diversity Center and is a Fellow of the American Chemical Society.

Descriere

Medicinal Chemistry teaches the essential concepts of medicinal chemistry from the perspective of practicing chemists, starting with a synthetic organic chemistry and structural biology foundation and interweaving coverage of therapeutics, case studies, historical context, and modern techniques. It is intended for advanced undergraduates and first-year graduate students in biology, chemistry, and biochemistry taking a one-semester survey course in medicinal chemistry.