Mercury (Hg) is a globally distributed pollutant that poses considerable risks to human and wildlife health. Over the past 150 years since the advent of the industrial revolution, approximately 80 percent of global emissions have come from anthropogenic sources, largely fossil fuel combustion. As a result, atmospheric deposition of Hg has increased by up to 4-fold above pre-industrial times. Because of their isolation, remote high-elevation lakes represent unique environments for evaluating the bioaccumulation of atmospherically deposited Hg through freshwater food webs, as well as for evaluating the relative importance of Hg loading versus landscape influences on Hg bioaccumulation.