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Metastatic Bone Disease: Fundamental and Clinical Aspects

Editat de Ingo J. Diel, Manfred Kaufmann, Gunther Bastert
en Limba Engleză Paperback – 22 dec 1993
"Metastatic Bone Disease: Fundamental and Clinical Aspects"is an expanded version of a workshop on bone metastaseswhich was held in Heidelberg, Germany, in April 1993. Bonemetastases very often develop from malignant tumors and leadto complications which considerably diminish the quality oflife of the patient. Bone pain, pathological fractures, andhypercalcemic syndrome should be recognized and treated ear-ly, so as to prevent any further morbidity and immobilizati-on. Antiosteolytic substances such as biophosphonate cansupplement the established palliative and supportive thera-pies.Highly qualified basic researchers and clinicians inpathophysiology, diagnosis, and treatment of metastatic bonedisease have contributed to this book, providing a goodoverview ofpresent knowledge and research. The book will beof interest not only to specialists, but also to any physi-cian interested in oncology.
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Specificații

ISBN-13: 9783540573562
ISBN-10: 3540573569
Pagini: 200
Ilustrații: X, 186 p. 25 illus.
Dimensiuni: 155 x 235 x 11 mm
Greutate: 0.29 kg
Editura: Springer Berlin, Heidelberg
Colecția Springer
Locul publicării:Berlin, Heidelberg, Germany

Public țintă

Research

Descriere

"Metastatic Bone Disease: Fundamental and Clinical Aspects"is an expanded version of a workshop on bone metastaseswhich was held in Heidelberg, Germany, in April 1993. Bonemetastases very often develop from malignant tumors and leadto complications which considerably diminish the quality oflife of the patient. Bone pain, pathological fractures, andhypercalcemic syndrome should be recognized and treated ear-ly, so as to prevent any further morbidity and immobilizati-on. Antiosteolytic substances such as biophosphonate cansupplement the established palliative and supportive thera-pies.Highly qualified basic researchers and clinicians inpathophysiology, diagnosis, and treatment of metastatic bonedisease have contributed to this book, providing a goodoverview ofpresent knowledge and research. The book will beof interest not only to specialists, but also to any physi-cian interested in oncology.

Cuprins

Historical Remarks on Metastasis and Metastatic Bone Disease.- Nature of Metastatic Bone Disease.- Incidence and Distribution of Bone Metastases.- Detection and Characterization of Tumor Cells in Bone Marrow of Patients with Primary Breast Cancer.- Normal Bone Remodeling and Metastatic Bone Disease.- Morphological Findings in Bone Metastasis, Tumorosteopathy and Antiosteolytic Therapy.- Mechanisms of Osteolytic Bone Destruction.- Diagnosis of Skeletal Metastases and Assessment of Response to Treatment.- Biochemical Markers of Bone Metabolism in Metastatic Bone Disease.- Palliative Radiotherapy of Bone Metastases.- Systemic Treatment of Bone Metastases: Review of Literature and Retrospective Analysis of 718 Breast Cancer Patients.- Bisphosphonates: Mechanism of Action and Clinical Use in Hypercalcemia of Malignancy and Tumor-Induced Bone Destruction.- Clodronate Decreases Skeletal Morbidity in Patients with Bone Metastases from Breast Cancer: A Double-Blind Randomized Controlled Trial.