The book includes novel technique to optimize minimum weight of orally disintegrating tablet and to meet the criteria of disintegration Micro encapsulation technique by top spray technology and optimize tablet by factorial design was challenging. Polymer eudragit EPO has special characteristics that it was remain as such in mouth and dissolve at 1.2 pH in stomach. As per my knowledge this research definitely useful for industries to develop such kind of formulation. Statistical analysis play major role for tablet optimization and ANOVA, Regression analysis, Contour plot, Surface response relationship minimize the time, cost and experiments for the research work.