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Migraine Pain Management: Current Pharmacological and Non-pharmacological Options

Editat de Stephen B. Shrewsbury
en Limba Engleză Paperback – noi 2024
Migraine Management: Current Pharmacological and Non-pharmacological Options is a comprehensive guide to established, recent, and ongoing pharmaceuticals and device development projects. The book provides detailed information on the historical developments of migraine pain management, druggable targets, drugs action mechanisms, drugs for acute treatment and preventive care of patients, administration routes, and alternative treatments. This is the ideal reference for academic researchers interested in anti-migraine pharmacology. It will also be a perfect reference for physicians and care professionals involved in the well-being of migraine patients.


  • Offers a comprehensive overview of pharmacological and alternative migraine pain treatment options
  • Covers the historical developments and current targets for drug development and delivery routes
  • Provides insights into comorbidities and their impact in patient compliance to treatment
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Specificații

ISBN-13: 9780443247057
ISBN-10: 0443247056
Pagini: 636
Dimensiuni: 216 x 276 mm
Greutate: 0.45 kg
Editura: ELSEVIER SCIENCE

Cuprins

Part I: Foundations and historical development of migraine pain management

1. Introduction
2. Neuroanatomy and Neurophysiology
3. Historical overview of migraine product development
4. Comorbidities and their impact on therapies
5. Not all Migraine attacks are the same
6. Challenges and Controversies; Pharmacokinetics, Linguistics, Semantics and Statistics

Part II: Druggable targets

7. CGRP
8. PACAP
9. Src family kinases (SFK) in Migraine
10. Delta opioid receptor system
11. Piezo channels in peripheral trigeminal nociception
12. TRP antagonists

Part III: Drugs – Acute Management

13. Simple analgesics and combination oral products
14. Cannabinoids & Phytochemicals
15. Ergots
16. Triptans
17. Beta blocker (timolol) eye drops
18. Lasmiditan (and the ditan class)
19. Gepants

Part IV: Drugs – Prevention

20. TCAs (Tricyclic Antidepresants), SNRIs, Beta blockers, candesartan, flunarizine
21. Antiseizure orals (gabapentin, topiramate)
22. Onabotulinumtoxin
23. Gepants (for prevention)
24. (CGRP) Monocloncal antibodies

Part V: Administration routes

25. Oral Drugs (including SMEDDS)
26. Inhaled - oral & nasal
27. Subcutaneous/IM/Transcutaneous ("Injectables")
28. IV/Infusion

Part VI: Alternative Management

29. The role of digital platforms and smartphone apps
30. Herbal Medicines
31. Phototherapy
32. Neuromodulation
33. Acupuncture (for episodic and chronic migraine)
34. Manual Therapies
35. Nutraceuticals and Diets
36. Mindfulness

Part VII: Summary & conclusion [Shrewsbury]

37. Final Perspectives: oral/non-oral pharmaceuticals; devices; Complimentary practices