Telomerase activity, hTERT and Survivin these markers with combined urinary cytology may give more sensitive diagnostic clues in bladder malignancies and by using this approach diagnosis of low grade tumor are also possible which was not detectable by earlier nioninvasive methods. Diagnostic future of telomerase is very positive because today it is confirmed that near about all tumor cells express telomerase, so telomerase can help in early diagnosis and this way patients can get better treatment.